This Week In Science (February 10-16, 2020)

1.) Scientists Discover the World’s Largest Bacteria-Eating Virus.

In an article published in the journal Nature, scientists reported that they had discovered the world’s largest virus. Clocking in at more than 735,000 base pairs, the virus is so large that it blurs the line between living and nonliving. Senior author, Jill Banfield of the University of California stated that these phages are “hybrids between what we think of as traditional viruses and traditional living organisms. This phages’ genome is much larger than the genomes of many bacteria. The virus was found during a survey of ecosystems around the world in an attempt to identify new virus types.

During the study, many new genes were discovered that coded for proteins that have not been previously discovered. These genes are not typical of other viruses, though similar genes are found in some bacteria species. The genes are normally used by the bacteria to fight off viral infections. The mechanism of action is similar to that of CRISPR-Cas9. The authors believe that the phage injects the DNA into the bacteria which hijacks the CRISPR-Cas9 system in the bacteria. This would help remove the competition from other phages and prevent them from infecting the cell. Other genes were also found that code for proteins that are required for a ribosome to function. Ribosomes are something that is not found in viruses and they are one of the cellular structures that are present in other life forms. The scientists believe that the virus uses these genes to code for proteins once it has infected the bacteria.

“Typically, what separates life from nonlife is to have ribosomes and the ability to do translation; that is one of the major defining features that separate viruses and bacteria, nonlife and life,” co-lead author Rohan Sachdeva, a research associate at UC Berkeley, said in a statement. “Some large phages have a lot of this translational machinery, so they are blurring the line a bit.”

Link

2.) Researchers Announce a New CRISPR Technique that Detects Abnormal Disease Signals in Cellular Genetic Regulatory Circuits.

In a study published in the journal Molecular Cell,  scientists announced that they had discovered a way to detect abnormal disease signals using CRISPR technology. The study authors used a split Cas12a platform to construct logic circuits. Each circuit allowed for multiple inputs and outputs. The researchers stated that the system is highly programmable and can create logic gates that are expandable and allow for anywhere from 2-4 inputs. They were also able to program in an “off” switch by using an anti-CRISPR protein. The next step was to couple this design to several tumor-relevant promoters in order to detect cancer.

This was a proof of concept study, but the authors showed that this system could detect breast cancer cells, and execute a therapeutic immunomodulatory response. This means that not only could it detect the tumor protein, but it was also able to immediately deploy a countermeasure. The study authors plan to continue to further develop this technology. Should they realize success, this study shows that they would be able to detect the unique tumor proteins before the cancer was able to establish itself in the patient, and could deploy the appropriate therapeutic response to resolve cancer easily. This is one more pathway for researchers to develop in order to continue the progression of better cancer treatments.

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3.) A Decrease in Limb Amputations Due to Critical Limb Ischemia

Copyright American Heart Association

In research published in Circulation: Cardiovascular Interventions, a journal of the American Heart Association, researchers announced that they had completed a retrospective analysis that showed positive trends in treating veterans diagnosed with critical limb ischemia (CLI). CLI is a disease of the arteries in the leg where they become critically narrow, causing severe leg pain, wounds that do not heal, and a poor quality of life. In the past, CLI has traditionally led to the amputation of the impacted limbs. CLI is also correlated with a much higher risk of heart attack and stroke. Researchers believe that the decrease in amputation rates is related to the development of new procedures to restore blood flow by using a surgical bypass or by the insertion of a stent. These procedures showed a demonstrable decrease in pain levels, improvement in wound healing, as well as a decrease in amputation rates.

Saket Girotra, M.D., S.M., senior author of the study and assistant professor of cardiovascular medicine at the University of Iowa Carver College of Medicine in Iowa City stated, “All patients with CLI should be evaluated to determine if they could benefit from a procedure to restore blood flow. In addition, patients with CLI should be aggressively treated with medications, including statins, blood pressure medications if they are hypertensive, and drugs to reduce platelet stickiness in order to reduce the risk of heart attack and stroke.”

To identify trends in treatments and outcomes, the researchers examined nationwide data from all VA facilities for nearly 21,000 patients (average age 68) who were hospitalized for CLI between 2005 and 2014. The researchers found that mortality decreased from 12% to 10%, amputation decreased from 20% to 13%, the new surgical procedures decreased mortality by 55% and amputation by 77%, and that there were sharp differences in the improvement rate among different VA hospitals. The best hospital showed a 53% improvement, while the worse shoed a mere 13%. “The disease may have been too advanced in some patients, making surgery or stenting not feasible, therefore, the only option was an amputation to limit the spread of infection and gangrene. A more in-depth study is needed to determine if revascularization was not offered to some patients who may have benefited,” Girotra said.

Link 

4.) New Discovery Could Make Solar Energy More Efficient

Claudia Turro

In a paper published in the journal Nature, scientists announced that for the first time have developed a single molecule that can absorb sunlight efficiently and also act as a catalyst to transform solar energy into hydrogen, a clean alternative to fuel for things like gas-powered vehicles. This new molecule collects energy from the entire visible spectrum and can harness more than 50% more solar energy than current solar cells can. The finding could help humans transition away from fossil fuels and toward energy sources that do not contribute to climate change. Lead author Claudia Turro, a professor of chemistry and director of the Ohio State University Center for Chemical and Biophysical Dynamics stated, “The whole idea is that we can use photons from the sun and transform it into hydrogen. To put it simply, we are saving the energy from sunlight and storing it into chemical bonds so it can be used at a later time.”

The researchers showed, for the first time, that it is possible to collect energy from the entire visible spectrum of sunlight — including low-energy infrared, a part of the solar spectrum that previously had been difficult to collect — and transform it, quickly and efficiently, into hydrogen. Hydrogen is a clean fuel, meaning it doesn’t produce carbon or carbon dioxide as a byproduct of its use.

“What makes it work is that the system is able to put the molecule into an excited state, where it absorbs the photon and is able to store two electrons to make hydrogen,” Turro said. “This storing of two electrons in a single molecule derived from two photons, and using them together to make hydrogen, is unprecedented.”

The research team figured out how to make a catalyst out of just one molecule using a form of the element rhodium. Using a single molecule means that less energy is lost when converting solar energy. Even more gains in efficiency were realized by the fact that the molecule could collect energy from the entire visible spectrum from infrared to ultraviolet. This led to efficiency which was 25 times more than previously developed single-molecule systems.

“I think the reason it works is that the molecule is difficult to oxidize,” Turro said. “And we have to have renewable energy. Just imagine if we could use sunlight for our energy instead of coal or gas or oil, what we could do to address climate change.” There are still additional development hurdles that must be overcome before the research can be developed into real-world applications.  Rhodium is a rare metal and producing catalysts from rhodium is expensive. The team is working on improving this molecule to produce hydrogen over a longer period of time and is working on building the catalyst out of less expensive materials.

Link

5.) Automation Poised to Take Over Half of all Jobs within 15 Years

According to the Accenture Technology Vision 2020 Report and Outlook 2019: The Future of Work, automation is poised to eliminate nearly half of all current jobs within the next 15 years. This is due to a variety of factors such as computer hardware improvements, new single-purpose algorithms, and the development of the automation engineering profession.  Accenture stated that companies need to balance ‘value’ with their stakeholder ‘values’ in order to successfully compete in a digital economy. To achieve this balanced approach, companies need to develop a new mindset and the ability to managing the clash between business and technology models that are incongruous with stakeholder’s needs and expectations.

While automation concerns nothing new, it does demonstrate that action needs to be taken before the automation crisis fully hits. Already, thousands of jobs have been lost due to the creation of automation, and entire industries are poised to shed the majority of their job positions as automation continues to improve.

Meanwhile, 79 percent of executives agree that work is shifting from roles to projects, challenging both the function and makeup of the workforce as we know it, said Tanushree Guha, managing director of Applied Intelligence and global lead for the Workforce Analytics practice at Accenture in the report titled “OCED Employment Outlook 2019: The Future of Work”.

Link

14,391 thoughts on “This Week In Science (February 10-16, 2020)

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    THE MAIN AIM:
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    6. Conducting tenders.
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    2.When sending mailing by feedback forms it is possible to send a few million messages per day to inbox folders. When sending e-newsletters a few thousands arrive in the inbox folders, all the rest often either do not reach or arrive in the junk.

    3. When sending mailing by contact forms a message does not get blocked by mail systems because it is sent from different internet resources. When sending bulk e-mails it is possible to send a few thousands of those but nevertheless all the IP addresses from which the mailing is done will be in “BAN”.

    4. When sending mailing by feedback forms the minimum number of macro-synonims is used to form text and headings of the letter. When sending bulk e-mails, it is necessary to use «macros» (synonyms) for each word and create ten thousand various headings.

    5. A lot of companies deliberatelly hide their e-mail address and only leave a contact form for contacting with them.

    6. When sending bulk e-mails, your commercial offer can be delivered to every employee of the firm, (which causes irritation) compared to mailing by feedback forms where the letter is received at the email specifically set up for cooperation offers.

    7.half of corporate e-mail addresses are placed on free mail servers, they are badly “searchable” by electronic address, but when sending mailing by feedback forms through these e-mail servers, all e-mails are one hundred percent delivered to the recipients.

    8. Only thirty-forty % of organisations are placed in the directories within two-three years, and all the other ones are already located in our VOIS databases and are waiting for your business offers.
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    9. Any kind of stop words in the headings or body of the message can be sent through contact forms. When sending mass e-mails, such messages either do not reach the recipient or arrive in a spam folder.
    The list of stop words of mails includes almost all words and phrases that encourage recipients to take actions.

    Application:

    1. Searching for new clients.
    2. Quick informing of marketplaces about new business offers.
    3. Reaching out company officials.
    4.demand analysis.
    5. Conducting tenders.
    6.Conducting marketing campaigns.
    7.Studying public opinion and conducting surveys.
    8. Searching for customers in international markets.

    Reasons for purchasing this service:

    1. 100-percent delivery of your e-mails and commercial offers to millions of firms around all countries in the world.
    Every internet resource sends a e-mail to itself so all filters of mails are bypassed.

    2.Mailing by contact forms is an great way in for conducting all sorts of researches of marketing, surveys and studies of social opinion on differenttype of activity and direction.
    When sending mailing by feedback forms, you will will be absolutely sure that your message has been delivered to 100% of consumers of your product and service and if a product or service is “poorly promoted”, then the potential issue lies in other things, for example in prices.
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    3.Mailing by feedback forms is the quickest and the most economical way to get your product or service to the international markets.

    4. Mailing by contact forms is a tool for conducting various tenders.

    5.Monthly update of the database, as more than one hundred and fifty thousand new sites, appear all over the world daily, and you, in turn, get potentially new customers.

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    8. Unique technology of unraveling the captcha.
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    9. By ordering mailing by feedback forms, you are promoting your service or product not to separate people, but to entire collectives, for instance domain zone .com, where more than one hundred and fifty million commercial organisations from all over the world are accumulated (we have samples of them from all international zones for every state).

    10. Mailing by feedback forms also includes a subtype of text mailing
    Email that is linked to the contact form is the primary email of firms through which applications and commercial offers are sent. This e-mail is also set up for cell phones as it is necessary to respond to the messages very fast so as not to misplace the order or the relevance of the business offer.

    11. The database of every country also includes all joint firms from all over the world working with or closely related to this country, for instance, national communities and diasporas.
    Sanctions of mail systems and search engines?
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    OUR DATABASES:
    You can purchase our databases separately from the mailing by sending us a request by contact form.

    MORE THAN 2000 WHOIS DATABASES BY DOMAIN ZONES AND COUNTRIES OF THE WHOLE WORLD.

    SELECTIONS OF DATABASES BY THE MAIN CONTINENTS OF THE WORLD.

    SELECTIONS OF DATABASES BY THE MAIN LANGUAGES.

    COLLECTIONS OF DATABASES BY THE MAIN WEBSITE BUILDERS.

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    HOW TO MAKE AN ORDER FOR MAILING BY FEEDBACK FORMS:
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    In the letter:
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    Your contact details:
    Site address:

    Fields to fill in:
    Name:
    Country:
    City:
    Internet resource:
    Several headings:
    E-mail address for autoresponces:

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    SEARCH ENGINE SANCTIONS:
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    Your actions:
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